As of Q1 2021, vaccines have started to reduce hospitalisations in numerous countries, but global variations in vaccine manufacturing, distribution, procurement and adoption ensure that 2021 will be a year of patchwork ‘new normals’ worldwide. New, more infectious and potentially more robust variants may render COVID-19 endemic, further fragmenting governments’ response. Despite the prominence of the pandemic, other issues (such as Brexit and data protection) have also been notable within searches.